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Investigating the role of Leucine Rich Repeat Kinase 2 (LRRK2) in human induced pluripotent stem cell derived macrophages

Abstract:

Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the most prevalent cause of familial PD. Genome Wide Association Studies (GWAS) have linked its variants with increased risk of developing sporadic PD, inflammatory bowel disease, and leprosy, diseases commonly associated with inflammation and immune dysfunction. LRRK2 is predominantly expressed in a subset of immune cells, notably macrophages and microglia and has been implicated in innate immunity. Yet, most studies report co...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
EU IMI StemBANCC More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Keywords:
UUID:
uuid:cb1bc671-6cdd-4b1b-80e3-2e45cb9bb527
Deposit date:
2019-04-10

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