Thesis
Investigating the role of Leucine Rich Repeat Kinase 2 (LRRK2) in human induced pluripotent stem cell derived macrophages
- Abstract:
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Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the most prevalent cause of familial PD. Genome Wide Association Studies (GWAS) have linked its variants with increased risk of developing sporadic PD, inflammatory bowel disease, and leprosy, diseases commonly associated with inflammation and immune dysfunction. LRRK2 is predominantly expressed in a subset of immune cells, notably macrophages and microglia and has been implicated in innate immunity. Yet, most studies report co...
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Authors
Contributors
+ Cowley, S
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
+ James, W
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Funding
EU IMI StemBANCC
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Keywords:
- UUID:
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uuid:cb1bc671-6cdd-4b1b-80e3-2e45cb9bb527
- Deposit date:
- 2019-04-10
Terms of use
- Copyright holder:
- Lee, H
- Copyright date:
- 2017
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