- Abstract:
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Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the most prevalent cause of familial PD. Genome Wide Association Studies (GWAS) have linked its variants with increased risk of developing sporadic PD, inflammatory bowel disease, and leprosy, diseases commonly associated with inflammation and immune dysfunction. LRRK2 is predominantly expressed in a subset of immune cells, notably macrophages and microglia and has been implicated in innate immunity. Yet, most studies report co...
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- Department:
- Sir William Dunn School of Pathology
- Role:
- Supervisor
- Department:
- Sir William Dunn School of Pathology
- Role:
- Supervisor
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Keywords:
- Copyright date:
- 2017
Thesis
Investigating the role of Leucine Rich Repeat Kinase 2 (LRRK2) in human induced pluripotent stem cell derived macrophages
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Authors
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+ Sally A. Cowley
+ William S. James
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