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Investigating the role of Leucine Rich Repeat Kinase 2 (LRRK2) in human induced pluripotent stem cell derived macrophages

Abstract:

Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the most prevalent cause of familial PD. Genome Wide Association Studies (GWAS) have linked its variants with increased risk of developing sporadic PD, inflammatory bowel disease, and leprosy, diseases commonly associated with inflammation and immune dysfunction. LRRK2 is predominantly expressed in a subset of immune cells, notably macrophages and microglia and has been implicated in innate immunity. Yet, most studies report co...

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Department:
Sir William Dunn School of Pathology

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Department:
Sir William Dunn School of Pathology
Role:
Supervisor
Department:
Sir William Dunn School of Pathology
Role:
Supervisor
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Grant:
WTISSF121302
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Grant:
LC0910-004
Funding agency for:
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Funding agency for:
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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