Journal article
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
- Abstract:
- After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its complex mechanisms of immune evasion. HIV-1 envelope glycoproteins are poorly recognized by the immune system, which means that potent broadly neutralizing antibodies (bnAbs) are only infrequently induced in the setting of HIV-1 infection or through vaccination. Thus, the biology of HIV-1–host interactions necessitates novel strategies for vaccine development to be designed to activate and expand rare bnAb-producing B cell lineages and to select for the acquisition of critical improbable bnAb mutations. Here we discuss strategies for the induction of potent and broad HIV-1 bnAbs and outline the steps that may be necessary for ultimate success.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 528.9KB, Terms of use)
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(Preview, Figures/images, pdf, 4.9MB, Terms of use)
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- Publisher copy:
- 10.1038/s41577-022-00753-w
Authors
- Publisher:
- Springer Nature
- Journal:
- Nature Reviews Immunology More from this journal
- Volume:
- 23
- Issue:
- 3
- Pages:
- 142-158
- Publication date:
- 2022-08-12
- Acceptance date:
- 2022-06-15
- DOI:
- EISSN:
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1474-1741
- ISSN:
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1474-1733
- Language:
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English
- Keywords:
- Pubs id:
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1264225
- Local pid:
-
pubs:1264225
- Deposit date:
-
2022-06-20
Terms of use
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2022
- Rights statement:
- © Springer Nature Limited 2022.
- Notes:
-
This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41577-022-00753-w
An Author Correction to this article was published on 01 March 2023, at: https://doi.org/10.1038/s41577-023-00854-0
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