Thesis
Gas propulsion of microprojectiles for the transformation of biological cells
- Abstract:
-
Bombardment of intact cells and tissue with DNA-coated microprojectiles represents a novel approach to the genetic transformation of biological material. In this thesis, a gas propulsion particle gun is developed for such a purpose. The particle gun utilises gas dynamics to control particle velocity and spread, thereby enabling optimisation of transformation efficiencies for varying types of target material. The dynamics associated with particle acceleration are shown to relate to transien...
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- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
-
uuid:c78bb189-665d-4199-8a0b-ce0b439389c7
- Local pid:
- polonsky:1:39
- Source identifiers:
-
603840975
- Deposit date:
- 2017-10-04
Terms of use
- Copyright holder:
- Sarphie, D; Sarphie, David Francis
- Copyright date:
- 1992
- Notes:
- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
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