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Thesis

The pathophysiological role of TDP-43 in amyotrophic lateral sclerosis due to C9orf72 mutations

Abstract:

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative condition that affects corticospinal and spinal motor neurons and leads to death within 30 months of symptom onset in half of all cases. It remains incurable and treatment is supportive. The genetic and molecular understanding of ALS has gone through a rapid expansion in recent years, notably with the discoveries of TDP-43, a heterogeneous ribonucleoprotein as a major component of neuronal inclusions in ALS, as well as the discover...

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Department:
Nuffield Department of Clinical Neurosciences

Contributors

Department:
Nuffield Department of Clinical Neurosciences
Role:
Supervisor
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Grant:
MR/L002167/1
Funding agency for:
Project
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Grant:
MR/L002167/1
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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