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Thesis

The pathophysiological role of TDP-43 in amyotrophic lateral sclerosis due to C9orf72 mutations

Abstract:

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative condition that affects corticospinal and spinal motor neurons and leads to death within 30 months of symptom onset in half of all cases. It remains incurable and treatment is supportive. The genetic and molecular understanding of ALS has gone through a rapid expansion in recent years, notably with the discoveries of TDP-43, a heterogeneous ribonucleoprotein as a major component of neuronal inclusions in ALS, as well as the discover...

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Division:
MSD
Department:
Clinical Neurosciences
Department:
Nuffield Department of Clinical Neurosciences
Role:
Author

Contributors

Department:
Nuffield Department of Clinical Neurosciences
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
UUID:
uuid:c5dd8dcf-c3e0-4ff7-ba9d-bfd3cb9914e8
Deposit date:
2018-02-26

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