Thesis
The pathophysiological role of TDP-43 in amyotrophic lateral sclerosis due to C9orf72 mutations
- Abstract:
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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative condition that affects corticospinal and spinal motor neurons and leads to death within 30 months of symptom onset in half of all cases. It remains incurable and treatment is supportive. The genetic and molecular understanding of ALS has gone through a rapid expansion in recent years, notably with the discoveries of TDP-43, a heterogeneous ribonucleoprotein as a major component of neuronal inclusions in ALS, as well as the discover...
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Authors
Contributors
+ Talbot, K
Department:
Nuffield Department of Clinical Neurosciences
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- UUID:
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uuid:c5dd8dcf-c3e0-4ff7-ba9d-bfd3cb9914e8
- Deposit date:
- 2018-02-26
Related Items
Terms of use
- Copyright holder:
- Scaber, J
- Copyright date:
- 2017
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