Thesis
The pathophysiological role of TDP-43 in amyotrophic lateral sclerosis due to C9orf72 mutations
- Abstract:
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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative condition that affects corticospinal and spinal motor neurons and leads to death within 30 months of symptom onset in half of all cases. It remains incurable and treatment is supportive. The genetic and molecular understanding of ALS has gone through a rapid expansion in recent years, notably with the discoveries of TDP-43, a heterogeneous ribonucleoprotein as a major component of neuronal inclusions in ALS, as well as the discover...
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Authors
Contributors
+ Kevin Talbot
Department:
Nuffield Department of Clinical Neurosciences
Role:
Supervisor
Funding
+ Motor Neurone Disease Association
More from this funder
Grant:
MR/L002167/1
Funding agency for:
Project
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
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Terms of use
- Copyright date:
- 2017
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