Structural studies of the PIR and RIFIN families from malaria-infected erythrocytes

Thesis

Malaria, caused by the Plasmodium parasite, is responsible for the deaths of close to half a million people a year. During the course of infection, the parasite invades and remodels the host red blood cell, often requiring the export of a number of proteins to the erythrocyte surface. These include the RIFIN family of Plasmodium falciparum, which have been shown to directly modulate the host immune response through interactions with inhibitory immune receptors such as LILRB1 and LAIR1. Add...

Expand abstract

Authors: Harrison, TE

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: RIFIN; Plasmodium; Malaria; LILRB1; CIR; PIR; falciparum
• Subjects: Biochemistry