Thesis
E-cadherin loss of function in the murine intestine
- Abstract:
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E-cadherin (Cdh1), is a major component of epithelial adherens junctions, binds the Wnt pathway effector β-catenin and is lost at the invasive edge of colon cancers. Crypt stem cells give rise to 4 cell lineages that, with the exception of Paneth cells, travel along the crypt-villus axis over 3 days and are shed by anoikis. Gain of function of the Wnt pathway by a mutation in Adenomatous Polyposis Coli (Apc) disrupts enterocyte turnover to result in adenoma formation. Hom...
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- Files:
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(Dissemination version, bin, 5.1MB, Terms of use)
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Authors
- Publication date:
- 2012
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:c5a61fcd-e0a2-4af7-bb53-c78c3a47874f
- Local pid:
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ora:12149
- Deposit date:
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2015-08-14
- ARK identifier:
Terms of use
- Copyright holder:
- Matheson, JAH
- Copyright date:
- 2012
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