Investigating potential allostery in the transcription factor CREB

Thesis

Intrinsically disordered proteins (IDPs) are incredibly prevalent in eukaryotic transcription factors as disorder in structure allows for great flexibility and multi-faceted pathways of signal transduction and protein regulation. The basic leucine zipper (bZIP) is one of the three eukaryotic disordered DNA-binding domains. One particular basic zipper, cAMP-response element binding protein (CREB), is predicted to be one of the most disordered proteins in the human genome. CREB is a major si...

Expand abstract

Authors: Chung, NL

• Type of award: MSc by Research
• Level of award: Masters
• Awarding institution: University of Oxford
• Language: English
• Keywords: IDP; Kinetics; Biophysics; CREB; Intrinsically disordered proteins; Transcription factor
• Subjects: Biophysics; Biochemistry