Investigating potential allostery in the transcription factor CREB

Thesis

Intrinsically disordered proteins (IDPs) are incredibly prevalent in eukaryotic transcription factors as disorder in structure allows for great flexibility and multi-faceted pathways of signal transduction and protein regulation. The basic leucine zipper (bZIP) is one of the three eukaryotic disordered DNA-binding domains. One particular basic zipper, cAMP-response element binding protein (CREB), is predicted to be one of the most disordered proteins in the human genome. CREB is a major si...

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Authors: Chung, NL

• DOI: 10.5287/ora-xmojp65mz
• Type of award: MSc by Research
• Level of award: Masters
• Awarding institution: University of Oxford
• Language: English
• Keywords: Biophysics; Intrinsically disordered proteins; CREB; Transcription factor; IDP; Kinetics
• Subjects: Biophysics; Biochemistry