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Properties of voltage-gated Na+ channels in pancreatic beta-cells

Subtitle:
Voltage-gated Na+ channels in beta-cells
Abstract:

Nav channels in rodent β-cells predominantly exhibit a hyperpolarised voltage-dependence of inactivation, which is so characteristic that it can be used for functional identification of β-cells. A smaller Na+ current component (10-15%) also exists that inactivates over physiological membrane potentials and contributes to action potential firing. It has been proposed that the currents contributing to inactivation over vastly different membrane potentials reflect the contribution of differen...

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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