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Thesis

Comprehensive assessment of the role of DNA methylation in obesity and type 2 diabetes

Abstract:

Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular and other diseases and are currently undergoing an increase in global prevalence. The work presented in my thesis addresses the role epigenetics, specifically DNA methylation, plays in the susceptibility to obesity and T2D and deals with methodological issues in the analysis of DNA methylation data.

I first combined epigenome-wide DNA methylation data across 38 adipose tissue samples with corresponding SNP a...

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Institution:
University of Oxford
Oxford college:
Christ Church
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Alexander Werner Drong
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:c2df87d9-9929-4eb1-8c44-61452b88ea3c
Local pid:
ora:11753

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