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Unravelling the role of AKR1D1 in human hepatocytes

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and is rapidly becoming one of the leading indications for liver transplantation worldwide. The cellular processes and molecular targets that govern disease development and progression remain to be fully defined and currently there are no licensed treatments. Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid hormones and catalyses a fundamental step i...

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Division:
MSD
Department:
RDM
Department:
University of Oxford
Role:
Author

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Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:c224fa03-040d-447e-9d25-ab268da26274
Deposit date:
2018-02-21

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