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Thesis

Catalytic methods for the synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes

Abstract:

Bicyclo[1.1.1]pentanes (BCPs) have emerged as useful bioisosteres for arenes in medicinal chemistry, demonstrating improved pharmacokinetic properties compared to the parent drugs. However, many syntheses still require the use of harsh conditions that are unsuitable for industrial applications. This thesis describes the development of new catalytic methodologies for the synthesis of 1,3-disubstituted BCPs, under mild conditions. Chapter 2 describes a photoredox-catalysed atom transfer radical...

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Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
ORCID:
0000-0002-4149-0494
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Name:
Engineering and Physical Sciences Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000266
Programme:
Synthesis for biology and medicine Centre for Doctoral Training
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:
Language:
English
Deposit date:
2023-01-26

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