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Thesis

MFS transporter superfamily: modelling and dynamics

Abstract:

The aims for this thesis were threefold. First, is it possible to develop a numbering protocol to aid homology modelling, despite the diversity of MFS sequences? Given these methods, apply these to improve the homology model of a putative MFS protein, SV2A. Finally, can Molecular Dynamics (MD) simulations be used to elucidate the transport mechanism in an MFS protein?

There are several solved X-ray crystal structures of secondary active transporter MFS proteins, all of which have a...

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Division:
MSD
Department:
Biochemistry
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:c1b28272-c35f-46a3-beee-92bb560933d8
Deposit date:
2016-02-07

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