Thesis
The role of autophagy in intestinal T cell homeostasis
- Abstract:
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A polymorphism in the essential autophagy gene ATG16L1 is associated with susceptibility to inflammatory bowel disease. However, the role of autophagy in maintenance of intestinal immune homeostasis remains unclear. Using targeted deletion of Atg16l1 in T cells, we demonstrate critical requirement for autophagy in generation of appropriate adaptive immune cell responses within the mucosa. Selective deletion of Atg16l1 in T cells resulted in spontaneous intestinal...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:c19d02d1-da2a-482e-8ba2-e2f88211a507
- Deposit date:
- 2016-04-04
Terms of use
- Copyright holder:
- Kabat, A
- Copyright date:
- 2015
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