Thesis
Arming ColoAd1 with tumor necrosis factor alpha and lymphotoxin alpha
- Abstract:
-
Colon and rectum cancers (CRCs) are the third most prevalent cause of cancer-related mortality. Advanced metastatic CRC has a very poor prognosis; indicating the need for improved therapy. Tumour necrosis factor (TNF) can induce an immune response against tumours and cause cell death of the tumour-associated vasculature. However, dose-limiting toxicity occurs with systemic TNF treatment. In order to assess the effects of expressing TNF and lymphotoxin α<...>
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Authors
Contributors
+ Fisher, K
- Department:
- Oncology
- Role:
- Contributor, Supervisor
+ Seymour, L
- Department:
- Oncology
- Role:
- Supervisor
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- UUID:
-
uuid:bfc9d84f-2677-45db-8705-791219446348
- Deposit date:
-
2016-09-26
Terms of use
- Copyright holder:
- Koelen, J
- Copyright date:
- 2015
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