Tumours in the newborn - a systematic review and review of grey
literature exploring differences in the types, treatments, and
outcomes of neonatal tumours in high income versus low-middle
income countries

Bonifacio, L

Oxford Thesis Collection

Thesis

Tumours in the newborn - a systematic review and review of grey literature exploring differences in the types, treatments, and outcomes of neonatal tumours in high income versus low-middle income countries

Abstract:: Neonatal Tumours are one of the least researched conditions in paediatrics and pose a significant surgical challenge due to the lack of accessibility to and standardization of treatment, especially in lower income regions of the world. Combining a systematic review and a review of grey literature, this research project explores how the types, treatments, outcomes, and parental perspectives of Neonatal Tumours differ across income levels, and it highlights a lack of literature in Low-Middle Income Countries.

The systematic review aims to examine existing literature regarding Neonatal Tumours. Thirty- four reviews were deemed eligible. These studies collectively reported on 2023 neonatal patients, with 1759 of these patients from High Income Level Countries, 178 of these patients from Upper Middle Income Level Countries, 86 of these patients from Lower Middle Income Level Countries and 0 from Low Income Level Countries. Overall Survival was 79.3%: 79.1% in High Income Level Countries, 71.9% in Upper Middle Income Level Countries, and 98.8% in Lower Middle Income Countries. These differences were found to be statistically significant. However, it is important to note the disparities in available patient data between country income levels. The lack of data in Low-Middle Income Level countries emphasizes a need for more research in these areas of the world.

The review of Case Reports dives into the grey literature on this subject, providing observations on types of tumours, demographics, and outcomes by country income level and discussing the importance of Case Reports in research. Using a novel system of categorization, case reports were sorted into five separate categories based on what each intends to present: Management suggestions/dilemmas (n=31), Diagnostic suggestions/dilemmas (n=16), report of a Unique Presentation of a case (n=12), report of a Rare Case (n=8), and Etiology / Pathogenesis of the disease (n=4).

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APA Style

Bonifacio, L. (2025). Tumours in the newborn - a systematic review and review of grey literature exploring differences in the types, treatments, and outcomes of neonatal tumours in high income versus low-middle income countries [Master's thesis]. University of Oxford.

MLA Style

Bonifacio, L. Tumours in the Newborn - a Systematic Review and Review of Grey Literature Exploring Differences in the Types, Treatments, and Outcomes of Neonatal Tumours in High Income versus Low-Middle Income Countries. 2025. University of Oxford, Master's thesis.

Chicago Style

Bonifacio, L. 2025. “Tumours in the Newborn - a Systematic Review and Review of Grey Literature Exploring Differences in the Types, Treatments, and Outcomes of Neonatal Tumours in High Income versus Low-Middle Income Countries.” Master's thesis, University of Oxford.
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