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Structural and functional studies of K2P channels

Abstract:

Two-pore domain potassium channels (K2Ps) are a family of dimeric potassium channels responsible for regulation of cellular excitability. In 2012, crystal structures of TREK-2 were solved revealing this channel in two different conformational states. In the down state, transmembrane helices M2, 3 and 4 descend further into the cytoplasm than in the up state. This reveals two gaps (fenestrations) that link the membrane directly to the ion conduction pathway. However, the functional relevan...

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Division:
MSD
Department:
NDM
Role:
Author

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Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
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UUID:
uuid:b9b6d390-a4d7-4353-bab2-478dadc50c4e
Deposit date:
2016-03-08

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