Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing

Thesis

In eukaryotes, recombination plays a critical role in both the production of viable gametes and as a population genetic process. Here, we are interested in studying recombination as it provides insight into a process that has shaped variation. To this end, we study the evolution of cross-over rates in chimpanzees and humans through two experiments.

Components of the recombination machinery are well described in yeast and C. elegans, but less so in other species. In humans, cross-ove...

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Authors: Venn, O

• Publication date: 2013
• DOI: 10.5287/ora-yrvq0gr0r
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: Genetic recombination; high-throughput nucleotide sequencing; meiosis; molecular evolution; comparative genomics
• Subjects: Mathematical genetics and bioinformatics (statistics); Medical Sciences