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Thesis

Mathematical modelling of drug-ion channel interactions for cardiac safety assessment

Abstract:

Unintended drug interactions with ion channels in cardiac cells can alter normal electrical activity in the heart. This can lead to the onset of cardiac arrhythmias which can be potentially fatal. Such arrhythmias are a leading cause of market withdrawal of pharmaceutical compounds. It is therefore important for pharmaceutical companies to identify drugs which may cause adverse changes to cardiac electrical activity as early as possible in the drug development process.

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Department:
University of Oxford

Contributors

Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
Department:
GlaxoSmithKline
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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