Thesis icon

Thesis

Characterising the Notch-ligand binding interaction, and its modulation by glycosylation

Abstract:

The Notch signalling pathway is universally conserved in all metazoan species, and is involved in many aspects of cell fate determination and tissue homeostasis, during development and in adult organisms. Several developmental diseases are associated with defective Notch signalling, and the Notch pathway has been implicated in a growing number of cancers.

The Notch signalling pathway requires direct cell-cell contact for ligand binding and receptor activation to occur. Specific doma...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Oxford college:
Lady Margaret Hall
Department:
Medical Sciences Division - Biochemistry
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:b6867987-f789-4da2-9444-992e481bb3e6
Local pid:
ora:7029
Language:
English
Keywords:
Subjects:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP