Thesis
Characterising the Notch-ligand binding interaction, and its modulation by glycosylation
- Abstract:
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The Notch signalling pathway is universally conserved in all metazoan species, and is involved in many aspects of cell fate determination and tissue homeostasis, during development and in adult organisms. Several developmental diseases are associated with defective Notch signalling, and the Notch pathway has been implicated in a growing number of cancers.
The Notch signalling pathway requires direct cell-cell contact for ligand binding and receptor activation to occur. Specific doma...
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Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Taylor, P
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:b6867987-f789-4da2-9444-992e481bb3e6
- Local pid:
- ora:7029
- Deposit date:
- 2013-07-17
Terms of use
- Copyright holder:
- Paul Taylor
- Copyright date:
- 2012
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