- Abstract:
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The Notch signalling pathway is universally conserved in all metazoan species, and is involved in many aspects of cell fate determination and tissue homeostasis, during development and in adult organisms. Several developmental diseases are associated with defective Notch signalling, and the Notch pathway has been implicated in a growing number of cancers.
The Notch signalling pathway requires direct cell-cell contact for ligand binding and receptor activation to occur. Specific doma...
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Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Funding agency for:
- Paul Brian Taylor
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
-
uuid:b6867987-f789-4da2-9444-992e481bb3e6
- Local pid:
- ora:7029
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Paul Taylor
- Copyright date:
- 2012
Thesis
Characterising the Notch-ligand binding interaction, and its modulation by glycosylation
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+ Biotechnology and Biological Sciences Research Council
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