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Journal article

Effects of sodium glucose co-transporter-2 inhibitors by diabetes status and level of albuminuria: a collaborative meta-analysis

Abstract:

Importance: There is uncertainty about the effects of SGLT2 inhibitors (SGLT2i) in certain types of patients with chronic kidney disease (CKD), with international guidelines offering different strengths of recommendation based on diabetes status and urine albumin:creatinine ratio (uACR) of ≥200 mg/g or <200 mg/g.

Objective: To assess the relative and absolute effects of SGLT2i in participants across the full range of efficacy and serious safety ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1001/jama.2025.20835

Authors

More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author

Contributors


Publisher:
American Medical Association
Journal:
Journal of the American Medical Association More from this journal
Volume:
335
Issue:
3
Pages:
220-232
Publication date:
2025-11-07
Acceptance date:
2025-10-14
DOI:
EISSN:
1538-3598
ISSN:
0098-7484


Language:
English
Keywords:
Pubs id:
2299882
Local pid:
pubs:2299882
Deposit date:
2025-10-15
ARK identifier:

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