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Thesis

Replication fork collapse and recombination-dependent replication restart at replication fork barriers

Abstract:

In order for the genome of any organism to be successfully replicated its replication machinery has to overcome barriers in the template DNA. These so-called replication fork barriers (RFBs) can sometimes cause the replication fork to collapse. Replication fork collapse is a poorly understood process that is thought to involve either replisome remodelling and/or disassembly paving the way for homologous recombination (HR) proteins to act and restart replication, by a process known as recom...

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Authors


Sanjeeta Tamang More by this author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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