Thesis
Development of pan-cancer immunotherapies to target stressed cells within the tumour microenvironment
- Abstract:
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Targeted cancer immunotherapies have been described as a ‘magic bullet’ which allow for the specific targeting of cancerous cells whilst leaving healthy cells unharmed. By targeting proteins that a highly upregulated in tumours, we can specifically target cancer cells for destruction via the immune system. The selecting of target protein or antigen is critical, the pressure of the therapy can lead to the emergence of clonal populations that have downregulated the target protein, leading to th...
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- Files:
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(Preview, Dissemination version, pdf, 8.8MB, Terms of use)
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Authors
Contributors
+ Lepuschuetz, L
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Oncology
- Role:
- Supervisor
- ORCID:
- 0000-0003-3825-0841
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Deposit date:
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2026-04-23
- ARK identifier:
Terms of use
- Copyright holder:
- Emma Louise Page
- Copyright date:
- 2024
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