Thesis
Protein folding
- Abstract:
-
Recent studies of the relationship between protein sequence and protein structure are reviewed. A detailed discussion of past attempts to predict the structure of a protein from its amino acid sequence, the protein folding problem, is presented and the strengths and weaknesses of these methods are examined. The root-mean-square deviation is studied and a benchmark for structural comparisons is established. A combinatorial approach to the protein folding problem is outlined and its advantages over existing methods is discussed. Specific algorithms based on the combinatorial approach are developed and applied to a variety of proteins. The success of this approach in terms of the root-mean-square deviation benchmark as well as the drawbacks of this method are presented.
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Authors
Contributors
- Role:
- Supervisor
- Role:
- Supervisor
- Role:
- Supervisor
- Role:
- Supervisor
- Publication date:
- 1980
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Subjects:
- UUID:
-
uuid:b2c493ae-3d76-47e4-b71e-d3e345924d71
- Local pid:
-
td:603839165
- Source identifiers:
-
603839165
- Deposit date:
-
2013-01-21
Terms of use
- Copyright holder:
- Cohen, F
- Copyright date:
- 1980
- Notes:
- The digital copy of this thesis has been made available thanks to the generosity of Dr Leonard Polonsky
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