Journal article
One- and 2-year incidence of osteoporotic fracture: a multi-cohort observational study using routinely collected real-world data
- Abstract:
-
Summary We estimated and characterized the imminent fracture risk (1–2 years) of high-risk fracture patients through a multinational (UK, Spain, Denmark) cohort study. Older individuals with newly diagnosed osteoporosis and individuals who had a fracture while on treatment with a bisphosphonate were at a high risk of imminent fracture.
Purpose To characterize and estimate 1- to 2-year fracture risk in high-risk fracture patients.
Methods Multi-cohort study in (database/study period) UK (CPRD/1995–2017), Spain (SIDIAP/2006–2016) and Denmark (DHR/1995–2016) including individuals ≥ 50 years old in NDO (newly diagnosed osteoporosis), OFx (incident osteoporotic fracture), BP (incident oral bisphosphonates use) or FWOT (fracture while on treatment with bisphosphonates). Outcomes (ICD-10/READ): hip, clinical spine, non-hip, non-spine and hip/humerus/distal forearm fracture. Follow-up: from cohort entry until death, migration/transfer or end of the study. Statistics: baseline characteristics and incidence rate (IR per 1000 persons).
Results (1-year IR) NDO included 69,899 (UK), 37,901 (Spain) and 158,191 (Denmark) individuals. Spanish-IR was lowest for hip (4.7), clinical spine (2.5) and major osteoporotic fracture (MOF) (17.3) and highest in Denmark (74.2, 26.0 and 120.1, respectively). OFx included 83,514 (UK), 51,044 (Spain) and 509,551 (Denmark) individuals. IR in Denmark was highest for hip (24.1) and MOF (47.2), in Spain was highest for the clinical spine (9.4) and lowest for hip (9.5) and in the UK was lowest for the clinical spine (2.8) and MOF (20.7). BP included 148,507 (UK), 52,037 (Spain) and 204,010 (Denmark) individuals. Spanish-IR was lowest for hip (5.0) and MOF (21.1) and highest in Denmark (20.3 and 48.6, respectively). FWOT included 28,930 (UK), 1,865 (Spain) and 31,882 (Denmark) individuals. Clinical spine-IR was highest for Spain (12.0). Hip-IR was lowest for Spain (7.6) and highest for Denmark (33.6). Comparing young subjects, those who have FWOT started with an increased fracture rate.
Conclusion OFx and FWOT individuals experience higher re-fracture incidence rates than those with osteoporosis with or without treatment.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Supplementary materials, 139.8KB, Terms of use)
-
(Preview, Version of record, 1.4MB, Terms of use)
-
- Publisher copy:
- 10.1007/s00198-021-06077-0
Authors
- Publisher:
- Springer
- Journal:
- Osteoporosis International More from this journal
- Volume:
- 33
- Issue:
- 1
- Pages:
- 123–137
- Publication date:
- 2021-08-15
- Acceptance date:
- 2021-07-19
- DOI:
- EISSN:
-
1433-2965
- ISSN:
-
0937-941X
- Language:
-
English
- Keywords:
- Pubs id:
-
1187062
- Local pid:
-
pubs:1187062
- Deposit date:
-
2021-07-20
Terms of use
- Copyright holder:
- Khalid et al.
- Copyright date:
- 2021
- Rights statement:
- © The Authors 2021. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
If you are the owner of this record, you can report an update to it here: Report update to this record