Role of cryptochromes in retinal responses to light

Thesis

Cryptochromes 1 and 2 (CRY1-2) are key components of the negative limb of the mammalian circadian clock. Like in many peripheral tissues, Cry1 and Cry2 are expressed in the retina where they are thought to play a role in regulating retinal circadian physiology.

This thesis investigates the role of Cryptochromes in the mammalian retina. The localization and expression pattern of CRY1 and CRY2 in the mouse retina are described, showing that CRY1 is expressed througho...

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Authors: Wong, J

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Cry1; Cryptochrome; magnetoreceptor; zeitnehmer; retinal rhythms; magnetoreception; retinal clock; Cry2
• Subjects: Magnetoreceptors; Magnetoreception; Contrast sensitivity (Vision); Pupillometry; Retina; Cryptochrome; Circadian rhythms; Electroretinography; Biological rhythms