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Thesis

Functional characterisation of synuclein-based novel genetic mouse models

Abstract:

Synucleins are highly conserved presynaptic proteins with unknown function. α-synuclein plays a key role regulating dopamine homeostasis and is intimately involved in Parkinson’s disease (PD) pathogenesis. However, the normal/pathological role of α-synuclein remains unidentified. Studies exploring its function are limited as current transgenic mouse models do not fully recapitulate PD pathology. This thesis reports the functional characterisation of two novel synuclein-based mouse models.<...>

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Institution:
University of Oxford
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
Role:
Author

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Supervisor
Role:
Supervisor
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Funding agency for:
Sabina Anwar
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:b14fc29e-2bc8-4a31-865b-f4ec0e0f6f2c
Local pid:
ora:12291

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