Thesis icon

Thesis

Heart function in mouse models of muscular dystrophy

Abstract:

Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused, in most cases, by the complete absence of the 427 kD cytoskeletal protein, dystrophin. Without dystrophin, the dystrophin-associated protein complex (DAPC) does not form and the plasma membrane is destabilised. There is no effective treatment and affected individuals die from respiratory failure and cardiomyopathy by age 30. This thesis describes experiments in which in vivo cardiac function was measured using non-i...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:b0dedd86-00d8-4f89-a197-3b78ab989524
Local pid:
ora:5726

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP