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Loss- and gain-of-function analyses of the role of MAP kinase signalling in testis determination

Abstract:

Sexual differentiation is the process by which an organism develops as either male or female. In mammals, this process is governed chromosomally, principally by the presence or absence of the Y chromosome. In the mouse, sex determination occurs at 11.5 days post coitum (dpc), when expression of Sry in the XY gonad kick-starts testis determination. SRY drives the subsequent expression of genes that both promote testis differentiation and inhibit ovarian differentiation, le...

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Department:
MRC
Role:
Author

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Department:
Mammalian Genetics Unit, MRC Harwell
Role:
Supervisor
Department:
Dept of Physiology, Anatomy and Genetics
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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