Thesis icon

Thesis

Loss- and gain-of-function analyses of the role of MAP kinase signalling in testis determination

Abstract:

Sexual differentiation is the process by which an organism develops as either male or female. In mammals, this process is governed chromosomally, principally by the presence or absence of the Y chromosome. In the mouse, sex determination occurs at 11.5 days post coitum (dpc), when expression of Sry in the XY gonad kick-starts testis determination. SRY drives the subsequent expression of genes that both promote testis differentiation and inhibit ovarian differentiation, le...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Department:
Physiology Anatomy & Genetics
Department:
MRC
Role:
Author

Contributors

Department:
Mammalian Genetics Unit, MRC Harwell
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Keywords:
Subjects:
UUID:
uuid:b02ff1d1-2b16-44f7-8008-7cd7867d1536
Deposit date:
2016-03-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP