Journal article
The pol II CTD: new twists in the tail
- Abstract:
- The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises conserved heptad repeats, and post-translational modification of the CTD regulates transcription and cotranscriptional RNA processing. Recently, the spatial patterns of modification of the CTD repeats have been investigated, and new functions of CTD modification have been revealed. In addition, there are new insights into the roles of the enzymes that decorate the CTD. We review these new findings and reassess the role of the pol II CTD in the regulation of gene expression.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pptx, 768.5KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 258.6KB, Terms of use)
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- Publisher copy:
- 10.1038/nsmb.3285
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Structural and Molecular Biology More from this journal
- Volume:
- 23
- Issue:
- 9
- Pages:
- 771-777
- Publication date:
- 2016-09-01
- Acceptance date:
- 2016-08-03
- DOI:
- EISSN:
-
1545-9985
- ISSN:
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1545-9993
- Pmid:
-
27605205
- Language:
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English
- Keywords:
- Pubs id:
-
pubs:641843
- UUID:
-
uuid:afbbcbec-e5f6-4653-b6e1-2b24299cff54
- Local pid:
-
pubs:641843
- Source identifiers:
-
641843
- Deposit date:
-
2016-09-23
- ARK identifier:
Terms of use
- Copyright holder:
- Zaborowska et al
- Copyright date:
- 2016
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: https://doi.org/10.1038/nsmb.3285
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