Investigating the recombinational response to replication fork barriers in fission yeast

Thesis

Timely completion of DNA replication in each cell cycle is crucial for maintaining genomic integrity. This is often challenged by the presence of various replication fork barriers (RFBs). On collision with a RFB, the fate of the replication fork remains uncertain. In some cases, the integrity of the fork is maintained until the barrier is removed or the fork is rescued by merging with the incoming fork. However, fork stalling can cause dissociation of all of the associated replication prot...

Expand abstract

Authors: Jalan, M

• Alternative title: Recombination dependent replication restart
• DOI: 10.5287/ora-pr8nxzran
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: homologous recombination; DNA Replication; replication restart; replication fork barriers
• Subjects: DNA repair; Genome Instability