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Effect of β2-adrenergic receptor agonists on neurotransmission and neuromuscular junction structure in congenital myasthenic syndromes

Abstract:

Background: β2-adrenergic agonists have been reported to be beneficial in patients with congenital myasthenic syndromes, in particular in those subtypes where postsynaptic structure is impaired. Although the β2-adrenergic receptor is well known for its muscle actions, its working mechanism at the neuromuscular junction is not understood.

Aims: It was hypothesized that β2-adrenergic agonists improve neurotransmission by ameliorating postsynaptic structure in ...

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Department:
Cambridge University

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
An Vanhaesebrouck
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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