Thesis icon

Thesis

Synthetic biology engineering to catalyse unbreakable linkage between peptide building blocks

Abstract:

Protein conjugation is an important tool for research and the development of novel therapeutics. Peptide tags are ideal handles for bioconjugation, as they are minimally disruptive to protein structure and function and are weakly immunogenic. In this thesis, I have developed SnoopLigase, a protein which is able to covalently link the two peptide tags SnoopTagJr and DogTag by site-specific transamidation. The three modules were obtained by splitting an isopeptide bond-containing domain of t...

Expand abstract

Actions


Access Document


Files:

Authors


Can Martin Buldun More by this author

Contributors

Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP