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Thesis

Genomic single molecule analysis of chromatin structure around DNA replication origins in Saccharomyces cerevisiae

Abstract:

Origin licensing initiates DNA replication by loading proteins on to DNA. In eukaryotes origin licensing varies among inactive replication origins and can be analysed by looking at chromatin structure. This has predominantly been studied using population-based approaches including MNase-seq. These mask the heterogeneity in interactions between DNA-binding events that occur on the same DNA molecule.

In this thesis the development of a single molecule genomic footprinting approach w...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Sub department:
Pathology Dunn School
Research group:
Replication Group
Oxford college:
University College
Role:
Author
ORCID:
0000-0003-0388-3673

Contributors

Division:
MSD
Department:
Pathology Dunn School
Sub department:
Pathology Dunn School
Role:
Supervisor
ORCID:
0000-0003-2001-076X
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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