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Investigating a role for telomeric transcription in cancer

Abstract:

A constitutive hallmark of cancers is the extension of telomeric DNA. Approximately 85% of cancers extend their telomeres through the upregulation of the enzyme telomerase; whereas the remaining proportion use a recombination-based method known as Alternative Lengthening of Telomeres pathway (ALT). Tumours that exhibit the so-called ‘ALT’ pathway include: pancreatic neuroendocrine tumours, astrocytoma and osteosarcoma. The prognosis for many of these tumours is poor and the developme...

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Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
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