Conformational states and immunological targeting of the arenaviral glycoprotein complex: implications for therapeutic design

Thesis

Envelope-displayed viral glycoproteins mediate host cell entry and are a key determinant of species tropism. As the glycoproteins are the sole antigens exposed on the mature virion surface, they are also primary targets of the host humoral immune response that arises during infection and immunisation. Macromolecular structure determination of these therapeutically important targets constitutes an important approach to obtain molecular-level insights into viral protein structure and functio...

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Authors: Ng, WM

• DOI: 10.5287/ora-0z5gjrnrp
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: cryo-electron microscopy; arenavirus; x-ray crystallography; viral glycoproteins; rabies virus
• Subjects: Structural biology; Molecular virology