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Thesis

Conservation and innovation - the evolution of the metazoan microRNA landscape and its contribution to reproduction and development

Abstract:

There are major gaps in our understanding of the evolution of microRNA (miRNA) genes and how this relates to evolutionary changes in metazoan development. miRNAs function as trans-acting post-transcriptional modulators of gene expression. They are implicated in the canalization of development and the consequent provision of evolvability. Here I present data and analyses on miRNA evolution in insects and mammals, both on a phylogenetic scale as well as at the level of individual mi...

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Supervisor
Agency for Science, Technology and Research, Singapore More from this funder
Elizabeth Hannah Jenkinson Fund More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:aabb8d6b-f92a-4b0f-94a5-0a2e6d7f7963
Deposit date:
2016-03-14

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