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Conservation and innovation - the evolution of the metazoan microRNA landscape and its contribution to reproduction and development

Abstract:

There are major gaps in our understanding of the evolution of microRNA (miRNA) genes and how this relates to evolutionary changes in metazoan development. miRNAs function as trans-acting post-transcriptional modulators of gene expression. They are implicated in the canalization of development and the consequent provision of evolvability. Here I present data and analyses on miRNA evolution in insects and mammals, both on a phylogenetic scale as well as at the level of individual mi...

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Department:
Department of Zoology, University of Oxford

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Department:
Department of Zoology, University of Oxford
Role:
Supervisor
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Grant:
268513
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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