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Thesis

Imaging neuroinflammatory processes with USPIO-MRI

Abstract:

This thesis examines the utility of USPIO-MRI to provide a tool of tracking macrophage recruitment to sites of neuroinflammation within the CNS. Recruited macrophages and microglia resident in CNS tissue play a key role in the pathophysiology of a number of neuroinflammatory diseases such as neuropathic pain and multiple sclerosis. Under activated conditions, microglia and macrophages will phagocytose invading cells and CNS debris. It has been shown that ultrasmall superparamagnetic partic...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Research group:
Experimental Neuroimaging Group, DPAG & FMRIB, Clinical Neurology
Oxford college:
Harris Manchester College
Role:
Author

Contributors

Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
More from this funder
Funding agency for:
Brown, AP
Publication date:
2009
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:aa1b5add-6a05-44ff-a270-5c31630f6577
Local pid:
ora:11592
Deposit date:
2015-06-05

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