Iridium-catalysed hydrosilylation of carbonyl derivatives: design and applications

Thesis

Chapter 1: the tertiary amide is a ubiquitous functional group and plays an irreplaceable role in medicinal chemistry. Its robust nature has meant – in the past – that selective manipulation of this motif remained elusive. The reductive activation through hydrosilylation of tertiary amides – using Vaska’s complex (IrCl(CO)(PPh3)2) – has emerged as a powerful strategy for the chemoselective transformation of amides into reactive enamines and iminium ions. Furthermore, these...

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Authors: Almehmadi, YA

• DOI: 10.5287/ora-amqxn65gm
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Subjects: Chemistry, Organic