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Exploring mechano-structural processes in osteoarthritis

Abstract:

Articular cartilage is a remarkable tissue with mechanical performance that surpasses engineering standards. Collagen, the most abundant protein in cartilage, plays an important role in this performance. Building on observations of collagen structural changes at the earliest stages of osteoarthritis, we here explore the role of collagen in the disease process. Specifically, we focus on the material properties and organization of collagen fibrils in the cartilage surface, seeking to answer ...

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ref 504
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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