Iron deficiency and human hypoxia physiology

Thesis

This thesis is concerned with a very common disorder of iron homeostasis: iron deficiency. The specific focus is the manner in which iron deficiency influences physiological responses to hypoxia in humans. This work is predicated on observations made over many decades in vitro and in vivo, suggesting that variations in the bioavailability of iron have important consequences for certain biological processes known to depend on oxygen availability.

Three separate but ...

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Authors: Frise, M

• DOI: 10.5287/ora-kzyxowaoy
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Skeletal muscle metabolism; Hypoxia-inducible factor; Iron deficiency; Chronic obstructive pulmonary disease; Hypoxic pulmonary vasoconstriction
• Subjects: Respiration; Energy metabolism; Human physiology