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Control of typhoid fever: evaluating herd protection through public health use of typhoid VI polysaccharide vaccine

Abstract:

Typhoid fever remains an important public health problem globally. Cluster randomized effectiveness trials with typhoid Vi polysaccharide vaccine were conducted in Kolkata, India and Karachi, Pakistan, to provide evidence for vaccine introduction. While efficacy trials are limited to estimate vaccine's performance on the vaccine recipients, effectiveness trials consider the public health impact, notably the herd protection, or indirect effect, which can only be seen when vaccines are admin...

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Institution:
University of Oxford
Oxford college:
Kellogg College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of

Contributors

Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:a6c8fa2f-66c7-46d8-9640-f1ebe3070113
Local pid:
ora:12332

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