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Thesis

Models of defective insulin secretion in human and mouse pancreatic islets: impact of granule exocytosis, mitochondrial metabolism, and ageing

Abstract:

Type-2 diabetes (T2D), a multi-factorial disease characterised by chronic hyperglycaemia, is caused by a complex interaction between genetic and environmental factors. Genetic and phenotypic characterisations of diabetic patients suggest that a combination of β-cell failure, culminating in defective insulin secretion, as well as impairment of glucagon secretion in α-cells is central to the aetiology of the disease. Mouse models represent a valuable tool in such investigations.

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:a6175acb-b2a2-4169-b144-0917cca8bafe
Local pid:
ora:12173
Deposit date:
2015-08-21

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