Thesis
Models of defective insulin secretion in human and mouse pancreatic islets: impact of granule exocytosis, mitochondrial metabolism, and ageing
- Abstract:
-
Type-2 diabetes (T2D), a multi-factorial disease characterised by chronic hyperglycaemia, is caused by a complex interaction between genetic and environmental factors. Genetic and phenotypic characterisations of diabetic patients suggest that a combination of β-cell failure, culminating in defective insulin secretion, as well as impairment of glucagon secretion in α-cells is central to the aetiology of the disease. Mouse models represent a valuable tool in such investigations.
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Authors
Contributors
+ Rorsman, P
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
+ Collins, S
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
-
uuid:a6175acb-b2a2-4169-b144-0917cca8bafe
- Local pid:
-
ora:12173
- Deposit date:
-
2015-08-21
Terms of use
- Copyright holder:
- Hyun-Woong Do
- Copyright date:
- 2015
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