Modelling the mechanisms of dynamic cerebral autoregulation and cerebrovascular reactivity in the human brain

Thesis

Healthy cerebral blood flow (CBF) control is vital to maintain sufficient oxygen perfusion to brain tissue and prevent brain damage. CBF is therefore controlled by, amongst others, two main global mechanisms: dynamic cerebral autoregulation (dCA), that responds to changes in arterial blood pressure (ABP) to keep steady state CBF near constant, and dynamic cerebrovascular reactivity (dCVR) that responds to vasoactive substances such as CO2. However, CBF control is impaired in a range of cerebr...

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Authors: Van Zijl, N

• DOI: 10.5287/ora-g7rvyoezd
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: mathematical models; physiology; cerebral blood flow regulation; cerebral autoregulation; impulse response; cerebrovascular reactivity
• Subjects: Cerebrovascular disease; Cerebral circulation; Mathematical models; Biomedical engineering