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Thesis

Discovery of epigenetic probes against the bromodomain family of proteins

Abstract:

Chemical probes are necessary for elucidating the biochemical roles of proteins. Bromodomains are protein-interaction modules found in a family of proteins implicated in the epigenetic regulation of transcription; however, the individual roles remain unknown for many bromodomain proteins, without potent and selective ligands available to assist in their study. From lead compounds, a structure-based drug discovery program was to be explored with the use of biophysical assays and appropriate...

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Peter Clark More by this author

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Supervisor
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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