Thesis
Using NMR to study protein-ligand interactions
- Abstract:
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The work described in this thesis focused on the use of nuclear magnetic resonance spectroscopy (NMR) to study two classes of metallo enzymes – the Fe(II)- and 2oxoglutarate (2OG)-dependent dioxygenases and the metallo β-lactamases (MBLs). These enzymes are involved in clinically important biological processes, i.e. the hypoxic response and antimicrobial resistance, respectively. Both protein systems are interesting from an NMR perspective because they have dynamic regions involve...
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(Preview, Dissemination version, pdf, 10.4MB, Terms of use)
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Authors
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:a4aa5995-625a-4814-8c91-e0114c1e2004
- Deposit date:
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2017-07-03
- ARK identifier:
Terms of use
- Copyright holder:
- Martine Abboud
- Copyright date:
- 2016
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