Thesis icon

Thesis

Modulation of the hypoxic response in cancer; inhibition of the HIF-1α/p300 protein-protein interaction

Abstract:

Hypoxia inducible factor (HIF)-1α is a heterodimerically-activated transcription factor central to the cellular response to hypoxic environments and is often upregulated in cancer. Binding of HIF-1α to the co-activator p300 is necessary for the hypoxia-induced transcription of many oncogenic proteins. The aim of this project was to develop novel small molecule inhibitors of the HIF-1α/p300 protein-protein interaction (PPI).

Initial work focused on designing, validating and optimisin...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Research group:
Hamilton and Schofield Groups
Oxford college:
St John's College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry

Contributors

Role:
Supervisor
Role:
Supervisor
More from this funder
Funding agency for:
Madura Jayatunga
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:a3ae9d39-f7cc-4ba5-b921-2a7855ee1512
Local pid:
ora:10481

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP