Thesis
The effects of exogenous ketosis on human metabolism, physiology, and endurance exercise performance
- Abstract:
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The (R)-3-hydroxybutyl (R)-3-hydroxybutyrate monoester, or ketone monoester (KME), provides an exogenous path to ketosis, with circulating concentrations of the ketone body β-hydroxybutyrate (βHB) elevated beyond those possible during a ketogenic diet within ~30 min of ingestion. As the consequent state of exogenous ketosis is one decoupled from the carbohydrate restriction obligate for endogenous ketosis and hence permits concurrent high-carbohydrate feeding, this presents a unique physiolog...
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(Preview, Dissemination version, pdf, 5.1MB, Terms of use)
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Authors
Contributors
+ Hodson, L
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Radcliffe Department of Medicine
- Sub department:
- RDM-Oxford Centre for Diabetes, Endocrinology and Metabolism
- Research group:
- L Hodson Group / Metabolic Research Group
- Oxford college:
- Green Templeton College
- Role:
- Supervisor
- ORCID:
- 0000-0002-2648-6526
+ Smith, K
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Radcliffe Department of Medicine
- Sub department:
- RDM-Oxford Centre for Diabetes, Endocrinology and Metabolism
- Research group:
- L Hodson Group / Metabolic Research Group
- Role:
- Supervisor
- ORCID:
- 0000-0001-7275-4379
+ Clarke, K
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Research group:
- Clarke Group
- Oxford college:
- Merton College
- Role:
- Supervisor
- ORCID:
- 0000-0002-3237-7553
+ Dearlove, D
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Radcliffe Department of Medicine
- Sub department:
- RDM-Oxford Centre for Diabetes, Endocrinology and Metabolism
- Research group:
- L Hodson Group / Metabolic Research Group
- Role:
- Supervisor
- ORCID:
- 0009-0002-9458-1418
+ Tyler, D
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Radcliffe Department of Medicine
- Sub department:
- RDM-Division of Cardiovascular Medicine
- Research group:
- Tyler Group
- Oxford college:
- Somerville College
- Role:
- Examiner
- ORCID:
- 0000-0002-0780-8905
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
-
- Subjects:
- Deposit date:
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2026-05-03
- ARK identifier:
Terms of use
- Copyright holder:
- Adam Isherwood
- Copyright date:
- 2025
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