Development of (Z)-alkenylsilane coupling methodology and application towards the synthesis of incednine

Thesis

This thesis describes the development of methods for the synthesis of incednam, the aglycon of incednine, via Hiyama cross-coupling. An early chapter discusses the efforts to improve upon previous efforts to access major building blocks. This is followed by a chapter focusing on the development of a novel strategy to access more reactive dimethyl alkenylsiloxanes and their applications. Finally, this new strategy is applied to the synthesis and different approaches to assemble incednam are explored.

Authors: Kuper, C

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford