Abstract:

This thesis describes the development of methods for the synthesis of incednam, the aglycon of incednine, via Hiyama cross-coupling. An early chapter discusses the efforts to improve upon previous efforts to access major building blocks. This is followed by a chapter focusing on the development of a novel strategy to access more reactive dimethyl alkenylsiloxanes and their applications. Finally, this new strategy is applied to the synthesis and different approaches to assemble incednam are explored.

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