Thesis
Targeting TFEB and TFE3 in iPSC-derived dopaminergic neurons to correct autophagic/lysosomal deficits in Parkinson's disease
- Abstract:
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Parkinson’s disease is characterised by the degeneration of dopaminergic neurons (DaNs). A key pathological hallmark within the remaining cells is the presence of proteinaceous intracellular aggregates. Clearance and recycling of damaged/aggregated proteins by the lysosome is pertinent to neuronal homeostasis and survival. Genetics, post-mortem study and disease modelling have implicated autophagic/lysosomal dysfunction as a key pathogenic mechanism contributing to PD. Mutations in PD-rela...
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- Files:
-
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(Preview, Dissemination version, pdf, 174.8MB, Terms of use)
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Authors
Contributors
+ Wade-Martins, R
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy & Genetics
- Sub department:
- Physiology Anatomy & Genetics
- Oxford college:
- Christ Church
- Role:
- Supervisor
+ Ryan, B
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy & Genetics
- Sub department:
- Physiology Anatomy & Genetics
- Role:
- Supervisor
- ORCID:
- 0000-0002-6703-3718
+ Hirst, W
- Institution:
- Biogen
- Oxford college:
- Christ Church
- Role:
- Supervisor
+ Guardado, C
- Institution:
- Biogen
- Role:
- Supervisor
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Funding agency for:
- McGuinness, W
- Programme:
- MRC-iCASE
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Pubs id:
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1754433
- Local pid:
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pubs:1754433
- Deposit date:
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2024-03-05
- ARK identifier:
Terms of use
- Copyright holder:
- McGuinness, W
- Copyright date:
- 2023
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