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Thesis

Regulation and function of innate-like T cells

Abstract:

KLRB1, encoding for CD161, is one of the most favourable prognostic pan-cancer genes. It is expressed by NK- and T-cell subsets, particularly by innate-like T cells such as MAIT and γδT cells. CD161-expressing T-cell subsets share a transcriptional and functional phenotype, including the ability to be activated by cytokines in a T-cell receptor-independent manner, similar to NK cells. The regulation and function of CD161-expressing cells as well as their role in cancer is not fully understood...

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Division:
MSD
Department:
NDM
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
More from this funder
Name:
Nuffield Department of Medicine
Funding agency for:
Hagel, JP
Programme:
NDM Prize Studentship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Deposit date:
2022-01-08

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